Interestingly, motor learning temporarily occludes artificially induced long-term potentiation (LTP) and increases induction of long-term depression (LTD) ( Rioult-Pedotti et al., 1998, 2000, 2007). When rats are trained on a motor skill, the evoked potentials elicited from the involved primary motor cortex (M1) are larger ( Rioult-Pedotti et al., 1998 Monfils and Teskey, 2004 Hodgson et al., 2005). Importantly, attempts to reverse the occlusion of LTP-like plasticity after motor learning comes with the cost of reducing retention of motor learning.Ĭhanges in the plasticity of synaptic connections are widely believed to play an essential role in learning and memory ( Martin et al., 2000). Altogether, these results provide evidence of a link between occlusion of LTP-like plasticity and retention and that this measure could be used as a biomarker to predict retention. Moreover, DePo stimulation over M1, but not over a control site, reversed the occlusion of LTP-like plasticity induced by motor learning and disrupted skill retention relative to control subjects. We found that the magnitude of motor memory retention is proportional to the magnitude of occlusion of LTP-like plasticity. We used transcranial magnetic stimulation to assess whether application of DePo over M1 after motor learning affected (1) occlusion of LTP-like plasticity and (2) retention of motor skill learning. Induction of LTP-like plasticity can be abolished using a depotentiation protocol (DePo) consisting of brief continuous theta burst stimulation.
Here we provide supporting evidence of it in humans.
Thus, it has been speculated that the occlusion of LTP-like plasticity after learning, indicative of how much LTP was used to learn, is essential for retention. Moreover, biochemical processes essential for LTP are also crucial for certain types of motor learning and memory. Human and animal studies have shown that motor learning results in long-term potentiation (LTP)-like plasticity processes, namely potentiation of M1 and a temporary occlusion of additional LTP-like plasticity. Plasticity of synaptic connections in the primary motor cortex (M1) is thought to play an essential role in learning and memory.
0 kommentar(er)
